What is Kisspeptin

Kisspeptin is a synthetic peptide derived from the natural KISS1 gene. It’s a synthetic analog of a natural compound your body produces, that acts upstream in your hormonal axis: 

• First, it’s triggering GnRH (Gonadotropin-releasing hormone) release in the hypothalamus;
• Next, GnRH boosts LH/FSH secretion
• And finally, LH and FSH ultimately boost your natural testosterone production. 

Unlike gear, Kisspeptin doesn’t aromatize, inject hormones, or shut your system down. It’s a reboot signal, a chain reaction starter that results in your testosterone going up. 

Kisspeptin Benefits

Kisspeptin-10 flips the switch on your HPTA by firing up GnRH, which then triggers LH and FSH — the two hormones that actually make your body produce testosterone and sperm. 

It’s perfect for guys coming off a heavy cycle, dealing with low LH levels, or just trying to get their natural system back ON without diving straight into TRT or blasting HCG.

Kisspeptin is especially useful for improving fertility, libido, and hormonal balance in lifters dealing with suppression or burnout. So, if you're recovering from a shutdown or fixing long-term hypogonadism, Kisspeptin supports full-spectrum hormonal recovery, starting from the brain. 

Here go all the benefits, in short: 

• Stimulates LH & FSH to restart natural testosterone production;
• Restores fertility and sperm production better than HCG alone;
• No estrogenic side effects (unlike Clomid or HCG);
• Improves mood and libido during the crash phase;
• Prevents testicular atrophy when used alongside or after a suppressive cycle.

And here's the kicker — it doesn’t just "look" like you’re recovering on paper. You actually feel like yourself again, faster.

Kisspeptin Side Effects

Side effects are rare, but it's not side effects-free. Here’s what can show up:

• Headaches;
• Mild flushing or dizziness;
• Injection site irritation (SubQ problems, nothing crazy);
• Nausea (rare, usually dose-related);
• Tachyphylaxis (aka your body stops responding if you overdo it or run it too long).

There’s no aromatization or estrogen conversion, but if you abuse the dose, you’ll crash your sensitivity fast and waste your whole protocol.

Kisspeptin Contraindications

Avoid Kisspeptin if you:

• Have pituitary damage or hypothalamic dysfunction (it won’t work if the signal path is broken);
• Are looking for a "blast and cruise" fix, this isn’t a cycle compound;
• Want a permanent testosterone level increase — this is support, not a miracle cure.

Also, it’s not ideal for women: Kisspeptin response varies wildly depending on menstrual phase and hormone sensitivity.

Kisspeptin Dosage

For a 5mg vial:

• Typical dose: 100-200mcg/day SubQ;
• Cycle length: 2-4 weeks for PCT, depending on severity of suppression;

For full shutdown cycles (e.g., Tren, Deca): Go toward the higher end, 200mcg/day;

For TRT alternative: Some use 100mcg/day, 5x/week (bloodwork required).

Don’t exceed 300mcg/day. More is not better. Your pituitary isn’t a punching bag, so treat Kisspeptin as a switch, not a lever.

How to Take Kisspeptin

Inject SubQ (aka, in the thin fat layer under your skin, most often in the belly area, abdomen or thigh), just like peptides or HGH. 

• Every day, same time, no need to split the dose;
• Start 24-48 hours after your last injection of gear;
• Don’t run it while still on-cycle. 
• Best injected with an insulin syringe.

Store reconstituted Kisspeptin in the fridge, it requires standard peptide handling and BAC water.

Kisspeptin has a short half-life, but its LH/FSH stimulation effect lasts longer, so you don’t need to microdose it like a madman.

Kisspeptin 5mg FAQ

Can Kisspeptin replace HCG?

Yes, for many users. It signals from the top of the hormonal chain, which means more complete recovery. HCG fakes LH, Kisspeptin restores it.

Can I use Kisspeptin during a cycle?

Nope. Bad idea. You’re just confusing your body. Use it post-cycle, or during TRT if you're experimenting with alternative stimulation.

Can I stack Kisspeptin with Clomid or Nolvadex?

Absolutely. In fact, combining it with Nolva or Clomid during PCT covers both ends — estrogen control and hormonal restoration.

Does Kisspeptin increase testosterone?

Indirectly, yes. By increasing LH and FSH, your own testosterone production comes back online — without suppressing anything further.