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ARIMIDEX
Arimidex is a very powerful anti-estrogen that is used to protect estrogens during the cycle. It belongs to the family of aromatase inhibitors (AI) and is one of the most widely used antiestrogens on the market. It was developed in the 1990s and marketed in 1995 as a treatment for breast cancer and as an anti-estrogen for anabolic steroid users.
Absorption of Arimidex is fast, the maximum concentration in the blood is reached within 2 hours after ingestion on an empty stomach. Food slightly reduces the rate of absorption. After a week of use, approximately 90-95% of the equilibrium plasma concentration of anastrozole (active ingredient) is reached. This drug works by blocking the aromatase enzyme. It is this enzyme, which is responsible for the production of estrogen, by an average of 80%. In addition to this, Arimidex stimulates the release of luteinizing and follicle-stimulating hormones, which control the production of natural testosterone in the blood.
Arimidex does not maintain progestogenic, androgenic, and estrogenic activity. The standard dose (10 mg) does not have any effect on the secretion of cortisol and aldosterone (therefore, when using the drug, replacement administration of corticosteroids is not required).
Benefits from Arimidex:
- used for patients with breast cancer - lowering circulating estradiol levels has a therapeutic effect in breast cancer patients, especially among postmenopausal women.
- beneficial for anabolic steroid users - highly appreciated for its ability to protect against estrogen-related side effects (like gynecomastia or water retention).
- lowering blood pressure - some steroids can cause this effect, which Arimidex can handle.
- used to increase testosterone levels - sometimes it can be included in PCT due to excellent stimulation of testosterone production.
Administration & Dosage
The medicine is taken orally by swallowing the whole tablet with water, always taken at the same time. The standard dosage of Arimidex for anabolic steroid users is 0.5-1 mg each other day. Athletes preparing for a competition should use 1 mg every day for 2 weeks before the competition.
Medicines containing estrogens reduce the pharmacological effect of the drug, so they should not be administered concurrently with it. Also, you should not prescribe Tamoxifen simultaneously with Arimidex, as it can weaken its pharmacological action.
Store the substance in a place protected from minors. Store at a temperature of the maximum of 30 ° C.
Side Effects
With the correct dosage and compliance with all indications for use, there should not be detected any side effects. Otherwise, the following may appear:
- From the digestive system: decreased appetite, nausea, vomiting.
- From the nervous system: drowsiness, anxiety, headache.
- From the respiratory system: bronchitis.
- From the side of hematopoiesis: anemia, leukopenia.
Others: allergic reactions, increased blood pressure, thrombophlebitis, increased ALP, AST, and ALT (in patients with liver metastases), "hot flashes" of blood to the face.
It is important to be careful while driving vehicles and taking part in other kinds of potentially dangerous activities that require an enhanced concentration of attention and quickness of psychomotor reactions while continuing the treatment with Arimidex,
Contraindications for use:
- an allergy to anastrozole or any other component of this drug.
- severe or moderate renal and hepatic impairment.
- taking estrogen drugs or tamoxifen.
- children under 18.
- Pregnancy.
- Lactation.
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