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Baclofen
Classification: GABA-derivative Skeletal Muscle Relaxant
Estrogenic Activity None
Progestational Activity None
Water Retention: None
Aromatization: None
Hepatotoxicity: None
Half-life: 2-4 hours
Recommended Dosage: 40-80 mg/day
Baclofen General Info
Baclofen is a medication developed in 1962 as a drug for treating epilepsy, but its effectiveness as a treatment of epilepsy was very insignificant. However, during clinical trials, it was noted that Baclofen significantly decreased muscle spasticity in some patients. And after years of research and multiple clinical trials, Baclofen was approved by FDA in 1977 as an effective treatment of muscle spasticity. Baclofen is the 122nd most prescribed drug in the USA that is widely used in clinical medicine, bodybuilding, and other sports.
Baclofen Pharmacodynamics
Baclofen is a derivative of Y-aminobutyric acid neurotransmitter that activates GABA receptors.
Baclofen's therapeutical effects in muscle spasticity result from its action in the brain and spinal cord.
Muscle spasticity
A condition of muscle performance combined with paralysis and hypertonia. Most commonly described as a prolonged stiffness and tightness of muscles.
Baclofen Effectiveness
Baclofen is an effective medication used for multiple health conditions.
Baclofen users' ratings on Baclofen effectiveness for specific medical conditions.
(10 being the highest rating)
Muscle Spasm 9 out of 10
Migraine Prevention 7 out of 10
Chronic Spasticity 8 out of 10
Neuralgia 7 out of 10
Hiccups 9 out of 10
Periodic Limb Movement Disorder 7 out of 10
Muscle Twitching 7 out of 10
Huntington's Disease 3.0 out of 10
Baclofen Administration
Appropriate and effective administration of Baclofen for muscle spasticity treatment.
Day 1-3
5mg three times a day
Day 4-6
10 mg three times a day
Day 7-9
15mg three times a day
Day 10-13
20 mg three times a day
Some users might need a more extended treatment with individualized dosages. Please do not exceed the maximum recommended dosage of 80mg/day (four intakes of 20mg/intake)
Baclofen Possible Side Effects
Baclofen is a very effective and safe compound. However, the overdose could lead to side effects such as diarrhea or constipation, upset stomach or throwing up, fatigue and weakness, headaches.