What is Spironolactone
Spironolactone is a diuretic, used by athletes to reduce water retention or bloating, reduce their water weight for increased muscle definition, or adjust the weight category before competition. The main difference between Spironolactone and loop diuretics is potassium retention.
Spironolactone doesn’t affect potassium excretion; therefore, it doesn’t cause as many cardiovascular issues as loop diuretics. However, it’s important to stay clear of exceeding the dosage to avoid electrolyte imbalance and its consequences.
Spironolactone Benefits
Even though Spironolactone causes weight loss, it is important to note that it can’t be called a fat-burning drug. Spironolactone excretes water and sodium, resulting in a lower water weight loss. It can be useful before bodybuilding or athletic competitions, or managing water retention.
Some anecdotal reports have concluded that Spironolactone can enhance fat loss by reducing testosterone levels in women.
Spironolactone Side Effects
The most common side effects of Spironolactone include:
- Drowsiness and lethargy;
- Headaches;
- Diarrhea and polyuria;
- Symptoms of dehydration: dry mouth, polydipsia.
Some users have noted that gaining muscle on Spironolactone is harder. To make progress, they have to put in more work and concentrate on intense strength training. There’s a concern about possible weight gain, although it can’t be directly linked to Spironolactone administration.
If the athlete leads an active lifestyle, avoids foods high in potassium, and watches his calorie intake, Spironolactone won’t cause any issues with weight.
Spironolactone Contraindications
Spironolactone isn’t recommended for people who have:
- An allergy to the active ingredient;
- Been diagnosed with kidney disease or have difficulties with urination;
- Found out about pregnancy or started breastfeeding.
For example, if the person has renal dysfunction, administering Spironolactone can cause hyperkalemia, swelling, or reduce renal function. It’s recommended to weigh the pros and cons before making a decision, preferably after a consultation with the medical advisor.
Spironolactone Dosage
The recommended dosage ranges from 60 mg to 100 mg once a day. An athlete shouldn’t take Spironolactone for long, only a day or two before competition or weigh-in. The maximum cycle length can’t exceed 5 days.
How to Take Spironolactone
When to take it |
Preferably in the morning, an hour before breakfast |
Dosage Instructions |
60 to 100 mg |
Cycle Length |
1–5 days |
Food Interaction |
Avoid potassium-rich foods |
Alcohol Interaction |
Limit alcohol consumption |
Drugs Interaction |
Spironolactone can’t be taken with Heparin, Lithium, ACEs and ARBs, Ibuprofen, or Aspirin. |
Best Stacks with Spironolactone
Spironolactone can be used with Lasix (Furosemide) for enhanced water weight loss. A person can take 50 mg of Spironolactone and 20 mg of Lasix to increase water and sodium excretion while keeping the dosage safe.
Spironolactone can be used with Hydrochlorothiazide as well. In this case, the combination of 50 mg Spironolactone to 50 mg Hydrochlorothiazide is optimal.
Common Questions About Spironolactone
Are Spironolactone and Hydrochlorothiazide the Same?
No, they are not. Even though Spironolactone and Hydrochlorothiazide are both classified as diuretics, they differ from each other. For example, Spironolactone is considered a mild diuretic, as it doesn’t change the potassium levels, whereas Hydrochlorothiazide can influence them.
Can Spironolactone Cause Weight Loss?
Spironolactone can cause water weight loss, but it won’t be effective for shedding extra pounds. The best results can be seen in people with a low-fat content percentage, as the drug allows for a short-term enhanced muscle definition.
Can Spironolactone Cause Weight Gain?
There are anecdotal reports of weight gain on Spironolactone, yet there is no correlation between administering the drug and adding pounds. If an athlete is adhering to his training regimen and maintains a proper diet, there’s no reason to worry about weight gain.
Brand: Pharmacy Grade, Apotex, Cobalt, Sandoz, TEVA
Substance: Spironolactone
Dosage and packing: 10 mg/tab (100 tabs)