What is Gonadorelin

Gonadorelin is a synthetic version of GnRH (Gonadotropin-Releasing Hormone) — the hormone your hypothalamus naturally makes to kick off testosterone and sperm production. 

It acts as a signal to your pituitary, telling it to release LH and FSH, and those two, in turn, fire up your test levels and fertility.

In short: Gonadorelin is the brain’s way of saying, “Hey, let’s turn the factory back on.” Unlike HCG (which fakes LH), Gonadorelin restores your actual hormone cascade. 

It's also used medically for treating hypogonadotropic hypogonadism, delayed puberty, and even fertility protocols like IVF.

Gonadorelin Benefits

Gonadorelin is a recovery-first compound. It doesn’t inject fake hormones, it wakes up your real ones. It forces your body to resume its own LH and FSH production, which means natural testosterone and fertility come back online.

Here’s what you get:

• Stimulates natural LH and FSH release;
• Improves fertility and boosts sperm count;
• Supports testicular function and basically testicular size;
• Used for treating hypogonadism and pituitary-related issues;
• Doesn’t aromatize or spike estrogen (e2, estradiol);
• Boosts libido, energy, and mood after suppression.

Gonadorelin Side Effects

Side effects are minimal, unless you’re somehow, for some reason, going overboard with the dose (which makes no sense in the first place).

What might show up:

• Headaches;
• Mild nausea or dizziness;
• Redness or irritation at the injection site;
• Tachyphylaxis (aka receptor burnout if you use it daily for too long).

No estrogen spikes. No liver stress. No shutdown like with HCG. However, abuse the dose or frequency, and you’ll desensitize your own GnRH receptors and kill the effect. Don’t be that guy.

Gonadorelin Contraindications

Don’t waste your time with Gonadorelin if:

• You’ve got serious pituitary or hypothalamic dysfunction (it’s a “straight to the doctor thing”);
• You’re trying to run it on-cycle — Gonadorelin won’t do anything when you’re still suppressed;
• You think this will turn you into a TRT monster — this is a recovery tool, not a muscle builder.

Also not built for women in bodybuilding. Yes, it’s used in IVF prep and reproductive medicine, but that’s a different setting entirely.

Gonadorelin Dosage

Here’s how to run it right, from a 2mg vial:

• Dose: 100-200mcg/day, SubQ;
• Cycle length: 2-4 weeks, depending on suppression;
• For deep shutdown (Tren, Dbol, Sdrol, long-term blasts): go 200mcg/day for 3-5 days, then taper down to 100mcg;

Don’t exceed 300mcg/day. Don’t run it more than 5 days straight at high doses.

NOTE: We’re talking mcg, not mg. You don’t want to run Gonadorelin in milligrams. 

How to Take Gonadorelin

• Inject SubQ — belly or thighs;
• Use an insulin pin;
• Once per day, same time.

Store in the fridge after reconstitution with BAC water.

And for the love of recovery, don’t microdose this forever. This is a short, targeted tool, not a long-term crutch.

Common Questions About Gonadorelin

Can Gonadorelin replace HCG?

Yes — and it does it better. HCG mimics LH. Gonadorelin actually restores LH and FSH by signaling your pituitary. Big difference.

Can I run it while on-cycle?

Nope. Useless during suppression. Save it for post-cycle when your system is ready to reboot.

Can I stack it with Nolva or Clomid?

Absolutely. That’s the smart play — Gonadorelin restarts the axis, while SERMs block estrogen and support testosterone feedback.

Does it raise estrogen?

Indirectly maybe, if your testosterone bounces back hard. But Gonadorelin itself doesn’t aromatize, convert, or cause estrogen issues.