FEMARA

Letrozole is a selective non-steroidal inhibitor of aromatase of the third generation. This drug decreases estrogenic side effects connected with aromatized anabolic/androgenic steroids gynecomastia, fat accumulation, and visible water retention. Athletes typically use it as a second line of treatment after an estrogen receptor antagonist such as Tamoxifen fails to elicit the desired response or starts as the first therapy cycle.

Letrozole also is responsible for selectively repressing the enzyme, which is responsible for the estrogen synthesis, thus blocking the synthesis of estrogen in both peripheral and tumor tissues, which means it also has an antiestrogenic impact. If you take the drug in a dosage of 0.1-5 mg, it will lead to a reduction in the amount of estradiol, estrone, and estrone sulfate in the blood plasma by 75-95% of the initial content. Throughout the treatment period, the suppression of estrogen synthesis in the body is maintained. If you use Letrozole in a dosage of 0.1 - 5 mg , you will meet no degradation of the production of steroid hormones in the adrenal glands in the body. Thus it is not required to administer glucocorticoids and mineralocorticoids.

It is one of the most potent estrogen-lowering drugs now. The drug is widely available in other countries, and currently, over 70 countries have Letrozole as an approved drug. The medicine is by far the predominant medicine worldwide and can be found in Australia, Canada, Czech Republic, France, Germany, India, Netherlands, Italy, Switzerland, and Russia.

Administration & Dosage

The drug is taken orally, and it is doesn't matter before, during, or after the meal. The standard dosage is 2.5 mg 1 time/day, for 4-8 weeks on average. The duration of the cycle selects individually; in some cases, the therapy can be prolonged. Absorption in the gastrointestinal tract is completed within 6-8 hours after ingestion. It is well absorbed and penetrates tissues and biofluids. Bioavailability - 80%, does not depend on food intake.

Do not take when there is a hypersensitivity to Letrozole, under 18, during pregnancy. Use caution if you have severe hepatic or renal impairment. Exercise caution with the simultaneous use of letrozole and potent inhibitors of isoenzymes CYP3A4 and CYP2A6, as they can reduce the metabolism of Letrozole, thereby increasing its serum concentration.

Storage - it is better to keep it in a dry place, at the maximal temperature of 25 ° C. 

Side Effects

Usually, side effects are quite light and associated with inhibition of estrogen synthesis. They are rare, but you may experience:

• nausea
• stomach ache
• headache
• dizziness
• irritability
• drowsiness
• insomnia
• depression
• increased heartbeat
• rash
• excessive sweating
• increased fatigue

If these side effects occur, it is necessary to contact a specialist who will decide whether to take Letrozole in the future.

If you experience drowsiness, dizziness, loss of concentration, you should avoid driving vehicles and controlling complex equipment.

Overdose has not been observed at the moment. If the dosage is accidentally exceeded, flush the stomach.