Erythropoieti

Erythropoietin alfa is a glycoprotein hormone, more specifically a cytokine. It stimulates the development of red blood cells (erythrocytes) from late progenitor cells, that's why we consider it as the principal regulator of erythropoiesis. The drug is capable of as well enhancing the exit of reticulocytes from the bone marrow, which will depend on oxygen consumption. The substance is a purified glycoprotein. Its biological and immunological qualities are the same, as possesses the human erythropoietin, which is producted in the kidneys and excreted with the urine. The production of endogenous erythropoietin depends on the blood oxygenation level.

The usage of Erythropoietin alfa guides to an expansion in hematocrit and hemoglobin levels in the blood, better blood supply to tissues, and improved heart function. It increases the number of red blood cells, which are responsible for transporting oxygen to the bloodstream, thereby increasing muscle and cardiovascular endurance, increasing energy levels and even enhancing protein synthesis. It is because of this that this drug is popular in sport and is often used by bodybuilders and athletes. This process is often related to blood doping.

EРО works in the body in very small concentrations, which makes it a very powerful hormone. Even little changes in the amount of EPO in the bloodstream lead to very big changes in the erythropoiesis rate. And in the human body, the number of erythrocytes must be constantly updated. You can buy Erythropoietin in a pharmacy or make an online order without any trouble.

Benefits and Effects of EPO:

• An increase in the number of erythrocytes under the influence of erythropoietin leads to an increase in the oxygen content per unit volume of blood and, accordingly, to an increase in the oxygen capacity of the blood and the delivery of oxygen to the tissues. Ultimately, the body's endurance increases. Thus, the oxygen transport function of hemoglobin is improved, which is the main purpose of the use of EPO as doping.
• EPO leads to the improvement in sports performance with a powerful manifestation of aerobic tolerance, because of the effect of EPO on the oxygen capacity and also its influence on the transfer of oxygen to tissues. These sports disciplines include all types of track and field running, as well as all types of cross-country skiing and cycling.
  Moreover, in recent publications, devoted to bodybuilding topics, the information has started to appear that it is possible for EPO to replace such massive use of anabolic steroids.
• Erythropoietin preparations are well-tolerated pharmacological agents that have practically no side effects. However, EPO overdose and uncontrolled use can lead to an increase in blood viscosity and, therefore, to an increased risk of circulatory disorders. Therefore, you must always monitor the state of your body and be sure to consult a doctor before using the drug.
• It is also possible to use EPO for treating treat anemia associated with chronic renal failure in adults, in cancer patients (who receive chemotherapy or no), in children on hemodialysis.
• During intensive training sessions and professional sports, you constantly need to conduct hematological analysis to determine the number of erythrocytes, their parameters (volume, hemoglobin saturation), hemoglobin level and hematocrit. The hematocrit should not exceed 50% - this leads to the thickening of the blood, which the microcirculation of blood in the muscles and internal organs worsens, which increases the risk of thrombosis. Besides, complete control of iron metabolism (total and unsaturated iron-binding capacity, percentage of iron saturation) and determination of the level of folic acid and vitamin B12 in the blood is required. All these tests are necessary for correct erythropoiesis, their deficiency should not be allowed during the period of sports activities.

Administration

The drug should be administered intravenously or subcutaneously. Use 22-25g syringes with a needle 1-1,5 inch long for intramuscular injections. Use 18-20g needle for intravenous injection.

How often you ought to take the medicine and the duration of the intake cycle is chosen individually.

The dosage of administration of Epoetin alfa will vary depending on your purpose of using it. The usual dosage is usually 50 to 100 units per kilogram of body weight in a therapeutic setting. Repeat it three times a week.

For athletes and bodybuilders, the dosage will be different, as they need to start with small doses: from about 5-10 units per kilogram of body weight. It should also be repeated three times a week for two weeks. Before starting to use EPO you should consult with your doctor. Continue using this drug as directed by your doctor even if you feel well.

You mustn't mix Epoetin alfa mixed with the intake of other medicinal substances.

Side Effects

If you use the drug wisely and with a prescription from a doctor, then there is practically no risk of side effects. But the rules of administration of the drug havebeen violated, the following symptoms may occur,:

• Irritation at the injection place
• High temperature
• Headache
• Vomiting and nausea
• Coughing
• Pain in bones, joint or muscles
• Muscle spasm
• Irritation or pain in the mouth
• Weight loss
• Sleep disturbances
• Symptoms of a cold

If the drug overdose has happened, you should call a Poison Control Center right away, and get medical help.

During the treatment period, you should be careful when driving vehicles or engaging in other hazardous activities that require increased concentration.